Peritoneal Mesonephric-Like Adenocarcinoma Arising in Endometriosis: Case Report and Review of the Literature Expanding the Spectrum of Extrauterine Mesonephric-Like Adenocarcinomas

p.G12V activating mutation.DiscussionMLA has a broad differential diagnosis and is often misinterpreted as other neoplasms. Accurate diagnosis requires an integrated assessment of morphology, immunophenotype, and molecular profile. The peritoneal location, particularly in association with endometriosis, raises the possibility of a peritoneal origin.ConclusionPeritoneal MLA is exceptionally rare. Pathologists should consider MLA in the differential diagnosis of peritoneal tumors, particularly those arising in the setting of endometriosis, to ensure accurate classification and appropriate clinical management.

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Publication Details

Journal
International Journal of Surgical Pathology
Published
2026-04-16
DOI
https://doi.org/10.1177/10668969261437122
Primary Topic
Endometriosis Research and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Peritoneal Mesonephric-Like Adenocarcinoma Arising in Endometriosis: Case Report and Review of the Literature Expanding the Spectrum of Extrauterine Mesonephric-Like Adenocarcinomas

Steven Blaine Holloway, Elena Lucas, Kareem Elfatairy, Jennifer Crow et al.
International Journal of Surgical Pathology
Endometriosis Research and Treatment
article

Peritoneal Mesonephric-Like Adenocarcinoma Arising in Endometriosis: Case Report and Review of the Literature Expanding the Spectrum of Extrauterine Mesonephric-Like Adenocarcinomas

Steven Blaine Holloway, Elena Lucas, Kareem Elfatairy, Jennifer Crow, Khaled Sabry Mohamed
article en

Abstract

p.G12V activating mutation.DiscussionMLA has a broad differential diagnosis and is often misinterpreted as other neoplasms. Accurate diagnosis requires an integrated assessment of morphology, immunophenotype, and molecular profile. The peritoneal location, particularly in association with endometriosis, raises the possibility of a peritoneal origin.ConclusionPeritoneal MLA is exceptionally rare. Pathologists should consider MLA in the differential diagnosis of peritoneal tumors, particularly those arising in the setting of endometriosis, to ensure accurate classification and appropriate clinical management.

International Journal of Surgical Pathology
Mansfield University (US), Southwestern Medical Center (US), OhioHealth Mansfield Hospital (US), Southwestern Medical Center (US), The University of Texas Southwestern Medical Center (US)
Gender equality
Openalex Percentile: Top 14%
Endometriosis Research and Treatment
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