Hypericin-Mediated Antimicrobial Photodynamic Therapy in Dentistry: A Systematic Review of Applications Against Oral Biofilms and Infections
Hypericin-mediated aPDT shows promising antimicrobial activity against oral pathogens and biofilms, with favorable selectivity and safety profiles. Nevertheless, the evidence remains predominantly preclinical and heterogeneous. Standardized protocols and well-designed clinical trials are required before routine dental implementation can be recommended.
Authors
- Maciej Dobrzyński (ORCID: https://orcid.org/0000-0003-2368-1534)
- Dariusz Roman Skaba (ORCID: https://orcid.org/0000-0001-8732-251X)
- Rafał Wiench (ORCID: https://orcid.org/0000-0001-5673-7413)
- Iwona Gregorczyk‐Maga (ORCID: https://orcid.org/0000-0002-1384-9439)
- Aleksandra Warakomska
- Radosław Turski
- Magdalena Pietrzko
Institutions
- Jagiellonian University (PL)
- Medical University of Silesia (PL)
- Wroclaw Medical University (PL)
- University of Bielsko-Biała (PL)
Publication Details
- Journal
- Pharmaceutics
- Published
- 2026-04-16
- DOI
- https://doi.org/10.3390/pharmaceutics18040491
- Primary Topic
- Photodynamic Therapy Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00