Administration of Topical NorLeu3Angiotensin(1-7) Minimizes Fibrotic Corneal Healing in Stellate Wound: A 28-Day Study
< 0.05). Additionally, 0.1% NLE reduced stromal TGFβR1, suggesting that NLE mediates its activity by disrupting the TGFβ/TGFβR axis. MasR and AT1R gene expression were downregulated, which contributes to a reduction in fibrosis. Collectively, these findings suggest that the NLE activation of MasR modulates RAS and TGFβ/TGFβR signaling to reduce myofibroblast activity and fibrosis following severe corneal trauma.
Authors
- Stan G. Louie (ORCID: https://orcid.org/0000-0001-5941-6690)
- Mark S. Humayun (ORCID: https://orcid.org/0000-0002-5830-5208)
- Juan Carlos Martinez Camarillo
- B Chen
- Catherine Chester
- Weiyuan Hu
- Edgar Alejandro Moreno-Diaz
- Maram Alshammari
Institutions
- University of Southern California (US)
- Southern California Eye Institute (US)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2026-04-16
- DOI
- https://doi.org/10.3390/ijms27083565
- Primary Topic
- Corneal Surgery and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Research to Prevent Blindness