Diagnostic Twins: Exploring the Radiohybrid Concept with Iodine-123 and Lanthanum-133 for PSMA-Targeted SPECT and PET Imaging
= 2.3-9.4 nM) and remarkable internalization rates up to 97% in vitro. In vivo studies using LNCaP tumor-bearing mice demonstrated comparable tumor uptake across all conjugates, regardless of the radionuclide. Advantageously, quantitative PET and SPECT blood measurements correlated closely with ex vivo data and metabolite analysis, additionally confirming the high in vivo stability with minimal deiodination during renal excretion and highlighting the suitability for dosimetric applications.
Authors
- Sven Stadlbauer (ORCID: https://orcid.org/0000-0003-2276-5330)
- Constantin Mamat (ORCID: https://orcid.org/0000-0003-1906-3186)
- Magdalena Blei (ORCID: https://orcid.org/0009-0009-1358-3560)
- Kristof Zarschler (ORCID: https://orcid.org/0000-0002-7571-4732)
- Santiago Andrés Brühlmann (ORCID: https://orcid.org/0000-0002-7840-6858)
- Martin Ullrich (ORCID: https://orcid.org/0000-0001-6104-6676)
- Jens Pietzsch (ORCID: https://orcid.org/0000-0002-1610-1493)
- Jonas Schädlich (ORCID: https://orcid.org/0009-0002-4550-0394)
- T Krönke
- Klaus Kopka
Institutions
- German Cancer Research Center (DE)
- Helmholtz-Zentrum Dresden-Rossendorf (DE)
- National Center for Tumor Diseases (DE)
- German Centre for Cardiovascular Research (DE)
- University Hospital Carl Gustav Carus (DE)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1021/acs.jmedchem.6c00161
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wilhelm Sander-Stiftung