Oxidized Phosphatidylcholines Regulate Secretory Phospholipase A2 Through Membrane Nanodomain Remodeling
function and provide mechanistic insight into how oxidative stress can differentially modulate inflammatory lipid signaling depending on membrane composition. This work highlights membrane organization as an active determinant of enzyme activity and a potential target in pathologies associated with oxidative stress, including atherosclerosis, neuroinflammation, and metabolic disease.
Authors
- Victoria Vitkova (ORCID: https://orcid.org/0000-0002-4098-7650)
- Biliana Nikolova
- Атанаска Еленкова (ORCID: https://orcid.org/0000-0001-9821-4952)
- Vesela Yordanova (ORCID: https://orcid.org/0000-0003-0753-8084)
- Rusina Hazarosova
- Albena Momchilova (ORCID: https://orcid.org/0000-0001-6608-0881)
- Galya Staneva (ORCID: https://orcid.org/0000-0003-2089-3603)
- Ralitsa Angelova
Institutions
- Bulgarian Academy of Sciences (BG)
- Georgi Nadjakov Institute of Solid State Physics (BG)
- Medical University of Sofia (BG)
Publication Details
- Journal
- Molecules
- Published
- 2026-04-16
- DOI
- https://doi.org/10.3390/molecules31081298
- Primary Topic
- Lipid Membrane Structure and Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Bulgarian National Science Fund