Clinical and Epidemiological Characteristics of Leptospirosis Cases Admitted to a District General Hospital in a High-Endemicity Area

Leptospirosis is a zoonotic disease caused by spirochetes of the genus Leptospira, primarily transmitted via direct or indirect contact with contaminated rodent urine. Human disease ranges from a mild, flu-like illness to severe, life-threatening Weil’s disease. Although the incidence of leptospirosis in Greece is not high, the Ionian Islands Region, including Corfu Island, presents the highest average frequency of cases in the country. A retrospective study of 11 confirmed cases in Corfu between 2015 and 2025 was conducted. The infections recorded during this period occurred from autumn to spring, exclusively affecting male patients in rural settings; notably, 90.9% of cases were attributed to occupational exposure. No association with urban or tourist areas was found. Although the incidence of the disease decreased by 42.1% compared to the previous decade (2005–2014), the case fatality ratio reached 27.3%, considerably above the average of 2.6% in Europe (during 2010–2022). The study underscores the need for enhanced clinical awareness and targeted preventive measures in Corfu, mainly among patients with at-risk occupations. Timely preparedness is needed especially in the face of ongoing climate change.