Green and Scalable Manufacturing of Biodegradable Polymer Scaffolds: Solvent-Free Processing, Supercritical CO2 and Melt Electrowriting

) technologies, melt electrowriting (MEW), and solvent-free processing techniques are the main topics of this study for a critical analysis of biodegradable polymer scaffold production techniques. Scaffold structure-property correlations, polymer selection and interactions, production procedures, the benefits and drawbacks of existing fabrication technologies, and sustainability issues are discussed in detail. It aims to contribute a novel perspective and approach to literature by presenting and comparing production-oriented approaches as sustainable and green methods. The challenges in the development of biodegradable tissue scaffolds, along with the significance of green manufacturing techniques, are also revealed. The approach is designed to connect processing factors to scaffold features in addition to evaluating current technologies. This review tries to offer a framework for producing biodegradable polymer scaffolds in a sustainable and clinically implementable context.