Plant pathogenic nematode exosomes remodel vector tracheae to enhance pathogen transmission
gene, leading to significant increases in ECM thickness and tracheal diameter, which consequently enhances nematode load. Collectively, this study identifies nematode exosomes as the delivery vehicle for Bx-miR-71-5p and defines a Notch-Mmp3-ECM axis through which pathogen signals remodel tracheal architecture to enhance vector competence and nematode load. These findings highlight that exosomes-mediated miRNA delivery may present a conserved "toolkit" that can tune vector traits, and ultimately facilitates pathogen transmission efficiency during invasion.
Authors
- Jianghua Sun (ORCID: https://orcid.org/0000-0002-9465-3672)
- Lilin Zhao (ORCID: https://orcid.org/0000-0002-3706-1267)
- Jin Zhou (ORCID: https://orcid.org/0000-0002-1534-2279)
- Yue Chang (ORCID: https://orcid.org/0009-0004-8500-0436)
- Fangyuan Ye
- Hongxia Zhang
Institutions
- Chinese Academy of Sciences (CN)
- National Institute of Ecology (IN)
- University of Chinese Academy of Sciences (CN)
- Hebei University (CN)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1073/pnas.2600386123
- Primary Topic
- Nematode management and characterization studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China