Alveolar type 2 cell LRP1 is needed for surfactant phospholipid metabolism and pulmonary function in mice
mice exhibited increased gene expression of detoxification and inflammatory pathways associated with COPD. Finally, query of public human data showed that T2C from patients with COPD have lower expression of LRP1 and lipid metabolic genes. These data show that LRP1 is needed in T2C for surfactant lipid metabolism and pulmonary function, and suggest that reductions of LRP1 expression promote smoke-associated fibrosis.
Authors
- Sangmi S. Park (ORCID: https://orcid.org/0000-0002-9486-8833)
- Michelle Mai (ORCID: https://orcid.org/0000-0002-9547-0958)
- Patrick Geraghty (ORCID: https://orcid.org/0000-0003-1647-5505)
- Igor Shmarakov (ORCID: https://orcid.org/0000-0002-4073-9585)
- Huchong Cai (ORCID: https://orcid.org/0000-0003-1057-0288)
- Ira J. Goldberg (ORCID: https://orcid.org/0000-0002-8701-2201)
- Jennifer Martinez (ORCID: https://orcid.org/0000-0002-3060-2518)
- Christina W. Agudelo (ORCID: https://orcid.org/0000-0002-9633-0308)
- Irina G. Stavrovskaya
- Elena López-Rodríguez (ORCID: https://orcid.org/0000-0002-1549-8150)
- Estela Área-Gómez (ORCID: https://orcid.org/0000-0002-0962-1570)
- Itsaso García‐Arcos (ORCID: https://orcid.org/0000-0002-4190-3252)
- Rafael ward
- Christopher Kiang
- Robert F. Foronjy
- Kimone Cox (ORCID: https://orcid.org/0009-0001-5093-3939)
- Soumya S. Krishnan
- Dativo Sanchez-Gonzalez
- Amrin Rahman
- Mattin Campos-Azpiroz
Institutions
- Rutgers, The State University of New Jersey (US)
- SUNY Downstate Health Sciences University (US)
- Columbia University Irving Medical Center (US)
- NYU Langone Health (US)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Journal of Lipid Research
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1016/j.jlr.2026.101042
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Heart Association
- Flight Attendant Medical Research Institute
- Else Kröner-Fresenius-Stiftung
- National Heart, Lung, and Blood Institute