Clinical Experience With Combined Pantoprazole and Pheniramine in the Treatment of Persistent Hiccups: A Case Series

Hiccups (singultus) are generally benign and self-limiting conditions; however, in some patients, they may become persistent and require treatment. Although proton pump inhibitors (PPIs), chlorpromazine, and various centrally acting agents are commonly used, evidence for alternative treatment options remains limited. While PPIs are frequently utilized for hiccups that develop secondary to dyspepsia, there is limited data in the literature to support antihistamines as an effective treatment modality, and clinical data supporting their use are also limited. This case series aimed to evaluate the clinical utility and safety of the combination of intravenous pantoprazole and pheniramine, an H1 antihistamine with anticholinergic properties, in the treatment of persistent hiccups.