Differential diagnostics of inflammatory changes and epithelial neoplasia of extrahepatic bile ducts

OBJECTIVE: To investigate the histological and immunohistochemical characteristics of epithelial neoplasia of the extrahepatic bile ducts (EHBD) and to develop a diagnostic algorithm. MATERIAL AND METHODS: <0.05). RESULTS: Based on the results of the morphological stage of the study, a scale for assessing the degree of dysplasia in biopsy specimens was developed; a certain number of points were assigned to each type of epithelial neoplasia of the EHBD. Based on the results of the IHC study, taking into account statistically significant changes, an immunophenotype was established for each type of epithelial neoplasia of the EHBD: inflammation and BilIN LG - MUC1, MUC2, MUC6, CD10; BilIN HG - MUC1, MUC2, MUC5AC, MUC6; IPNB LG - MUC1, MUC2, MUC5AC, MUC6, CD10; IPNB HG - MUC1, MUC2, MUC5AC, MUC6; CC - MUC1, MUC5AC, MUC6. For differential diagnosis of the degree of dysplasia in epithelial neoplasia of the EHBD, it is recommended to use an IHC panel with the presence of antibodies to MUC1, MUC2, CD10. It is proposed to use antibodies to MUC2, MUC5AC and MUC6 as an IHC panel for differential diagnosis of IPNB subtypes. CONCLUSION: Clear morphological and immunohistochemical criteria for the differential diagnosis of non-invasive lesions of the EHBD, inflammation and cholangiocarcinoma have been identified, and an algorithm for the comprehensive differential diagnosis of epithelial neoplasia of the EHBD has been developed.