Periocular Rejuvenation with PRF Gel

Aim and Background: Age-related changes in the periorbital region contribute to tear trough deepening and infraorbital hollowing, which create a fatigued appearance. Historical Aspect: Platelet concentrates have been used for many years for their regenerative capabilities. Platelet-rich fibrin (PRF) Gel has recently been introduced as a natural alternative to hyaluronic acid (HA) fillers for periorbital rejuvenation. Anatomy: The main cause for periorbital hollowness is volume loss in the fat pads, most specifically the sub-orbicularis oculi fat (SOOF). Patient Selection: PRF Gel is well-suited for patients seeking a conservative approach, especially those with prior HA-related complications or compromised lymphatic drainage. Techniques: PRF Gel is created by combining denatured albumin (2,600 rpm, 7 minutes) with liquid PRF (1,100 rpm, 5 minutes) in a 3.5:1.5 cc ratio to form an injectable gel. Postoperative Care: Treatment requires minimal downtime and fewer restrictions compared to HA fillers. Current and Future Development: Prospective observations show progressive volume improvement with repeated treatments. Refinement of centrifugation and protocols may further enhance clinical outcomes. Conclusion and Clinical Relevance: PRF Gel offers a new and autologous treatment to patients who are seeking a more conservative and natural approach to under-eye rejuvenation.