Repurposing Product Nkabinde for Hepatitis B Virus Therapy: A Network Pharmacology and Molecular Docking Investigation
: Together, these results demonstrate that the components of PN possess strong multitarget binding capabilities across the PI3K/AKT, JAK-STAT, SRC-family kinase, EGFR, and SYK pathways, supporting their potential repurposing as host-directed HBV therapeutics with the ability to impede immune evasion, viral persistence, and HBV-associated oncogenic progression.
Authors
- Magugu Nkabinde
- Siphathimandla Authority Nkabinde
- Samuel Chima Ugbaja (ORCID: https://orcid.org/0000-0002-1856-5697)
- Nceba Gqaleni
Institutions
- Africa Health Research Institute (ZA)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2026-04-16
- DOI
- https://doi.org/10.3390/ph19040627
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Inyuvesi Yakwazulu-Natali