Discovery of New Teraryl γ-Lactam Derivatives as Potent Antibacterial Agents <i>In Vitro</i> and <i>In Vivo</i> through Dual Cell Wall–Membrane Inhibitions
anti-MRSA efficacy. This novel scaffold is a promising addition to the antibiotic arsenal and warrants further development.
Authors
- Yongxu Zhao (ORCID: https://orcid.org/0000-0003-4668-8165)
- Dongliang Guan (ORCID: https://orcid.org/0000-0002-7814-1116)
- Jingwen Liao (ORCID: https://orcid.org/0009-0003-4077-3841)
- Taopeng Chang
- Feifei Chen (ORCID: https://orcid.org/0000-0002-7251-1956)
- Jinyong Zhang (ORCID: https://orcid.org/0000-0001-9622-5834)
- Fang Li (ORCID: https://orcid.org/0009-0001-5124-0229)
- Zhifu Chen
- Dianyan Chen
- Lishu Sheng
- Yitong Hu
- Yue Yuan
- Jinhua Dong (ORCID: https://orcid.org/0000-0003-2951-0939)
Institutions
- Shenyang Pharmaceutical University (CN)
- Army Medical University (CN)
- Chinese Academy of Sciences (CN)
- Anhui University of Traditional Chinese Medicine (CN)
- Shanghai Institute of Materia Medica (CN)
- Advanced Research Institute (US)
- Institute for Advanced Study (DE)
- University of Chinese Academy of Sciences (CN)
- Army Medical College (PK)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1021/acs.jmedchem.6c00136
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00