Exploratory Single-Nucleus RNA Sequencing Suggests Glial-Specific NPY Upregulation and Cell-Type-Specific Metabolic Alterations in Temporal Lobe Epilepsy

expression, though not statistically significant. Given the limited cohort size, these results should be interpreted as exploratory. They provide a cell-type-resolved candidate framework for future mechanistic studies of glial-associated responses in human epilepsy.

Authors

Yaning Ding
Le Su (ORCID: https://orcid.org/0000-0003-2810-1703)
Chao Jiang (ORCID: https://orcid.org/0000-0002-9228-1924)
Shanshan Wu (ORCID: https://orcid.org/0000-0002-4421-8808)
Zhiqiang Cui (ORCID: https://orcid.org/0009-0008-0444-8810)
Chuang Guo
Chenyang Bai
Yan Zhao
Jian Wang

Institutions

North China University of Science and Technology (CN)
Chinese General Hospital College of Nursing and Liberal Arts (PH)
Hainan 301 Hospital (CN)
Chinese People’s Liberation Army 263 hospital (CN)
Northeastern University (CN)

Publication Details

Journal: Biology
Published: 2026-04-16
DOI: https://doi.org/10.3390/biology15080627
Primary Topic: Neuroinflammation and Neurodegeneration Mechanisms
Type: article
Field-Weighted Citation Impact: 0.00

Funders

National Natural Science Foundation of China
National Science and Technology Major Project

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article

Exploratory Single-Nucleus RNA Sequencing Suggests Glial-Specific NPY Upregulation and Cell-Type-Specific Metabolic Alterations in Temporal Lobe Epilepsy

Yaning Ding, Le Su, Chao Jiang, Shanshan Wu et al.

Apr 16, 2026

Biology

Neuroinflammation and Neurodegeneration Mechanisms

article

Exploratory Single-Nucleus RNA Sequencing Suggests Glial-Specific NPY Upregulation and Cell-Type-Specific Metabolic Alterations in Temporal Lobe Epilepsy

Yaning Ding, Le Su, Chao Jiang, Shanshan Wu, Zhiqiang Cui, Chuang Guo, Chenyang Bai, Yan Zhao, Jian Wang

April 16, 2026article en

Abstract

expression, though not statistically significant. Given the limited cohort size, these results should be interpreted as exploratory. They provide a cell-type-resolved candidate framework for future mechanistic studies of glial-associated responses in human epilepsy.

BiologyVol. 15(8)

North China University of Science and Technology (CN), Chinese General Hospital College of Nursing and Liberal Arts (PH), Hainan 301 Hospital (CN), Chinese People’s Liberation Army 263 hospital (CN), Northeastern University (CN)

National Natural Science Foundation of China, National Science and Technology Major Project

Affordable and clean energy

Openalex Percentile: Top 20%

Neuroinflammation and Neurodegeneration Mechanisms

DOI Open Access PDF OpenAlex

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Exploratory Single-Nucleus RNA Sequencing Suggests Glial-Specific NPY Upregulation and Cell-Type-Specific Metabolic Alterations in Temporal Lobe Epilepsy — Yaning Ding, Le Su, et al. · Biology (2026) | TGRS Research Map | TGRS