Characterizing Individuals Fulfilling Clinical Criteria for Limbic-Predominant Age-Related TDP-43 Encephalopathy in a Tertiary Memory Clinic

BACKGROUND AND OBJECTIVES: Limbic-predominant age-related TDP-43 encephalopathy (LATE) is characterized by an amnestic- and limbic-predominant phenotype, which can mimic Alzheimer disease (AD). In a memory clinic cohort, we tested whether clinical criteria for LATE can detect a clinical profile of LATE that is distinct from AD. METHODS: In this retrospective examination of a longitudinal memory clinic cohort from the Alzheimer Center Amsterdam, we included individuals with mild cognitive impairment (MCI) and dementia (aged >50 years). We classified individuals based on baseline data on cognition, atrophy, amyloid-status, and tau-status into Probable- and Possible-LATE, co-occurring LATE and AD (LATE-AD), and AD (without LATE). Next, we compared these groups on demographics, clinical features, cognition, and atrophy. RESULTS: < 0.01). DISCUSSION: Using an operationalization of clinical criteria for LATE, 8.2% of participants with MCI or dementia from our tertiary memory clinic were classified as Possible-LATE, Probable-LATE, or LATE-AD. Probable-LATE was characterized by a milder disease course than AD, whereas LATE-AD was characterized by a more aggressive disease course. This underscores the value of the proposed clinical criteria in identifying individuals with suspected LATE, who have distinct clinical trajectories from AD. Our findings, therefore, support the use of these criteria to improve diagnostic and prognostic accuracy in the memory clinic.

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Journal
Neurology
Published
2026-04-16
DOI
https://doi.org/10.1212/wnl.0000000000214810
Citations
1
Primary Topic
Traumatic Brain Injury Research
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article
Field-Weighted Citation Impact
20.01
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article

Characterizing Individuals Fulfilling Clinical Criteria for Limbic-Predominant Age-Related TDP-43 Encephalopathy in a Tertiary Memory Clinic

Lyduine E. Collij, Diana I. Bocancea, Roos M. Rikken, Annemieke J.M. Rozemüller et al.
1 citations
Neurology
Traumatic Brain Injury Research
20.01
article

Characterizing Individuals Fulfilling Clinical Criteria for Limbic-Predominant Age-Related TDP-43 Encephalopathy in a Tertiary Memory Clinic

Lyduine E. Collij, Diana I. Bocancea, Roos M. Rikken, Annemieke J.M. Rozemüller, Flora H. Duits, Laura E. Jonkman, Rik Ossenkoppele, Ilse Bader, Sophie E Mastenbroek, Wiesje M. van der Flier, Emma M. Coomans, Marie R. Vermeiren, Elsmarieke van de Giessen, Colin Groot, Charlotte Elisabeth Teunissen, Annelies E. van der Vlies, Casper de Boer, Suzie Kamps, Alex J. Wesseling, Yolande A.L. Pijnenburg, Hannah de Bruin, Betty M. Tijms, Anna E. Leeuwis, Maria Carrigan, Bas G.J. van Tol, Ye Xia, Ismael L. Calandri, Frederik Barkhof, Afina W. Lemstra, Lotte A. de Koning
article en
1 citations

Abstract

BACKGROUND AND OBJECTIVES: Limbic-predominant age-related TDP-43 encephalopathy (LATE) is characterized by an amnestic- and limbic-predominant phenotype, which can mimic Alzheimer disease (AD). In a memory clinic cohort, we tested whether clinical criteria for LATE can detect a clinical profile of LATE that is distinct from AD. METHODS: In this retrospective examination of a longitudinal memory clinic cohort from the Alzheimer Center Amsterdam, we included individuals with mild cognitive impairment (MCI) and dementia (aged >50 years). We classified individuals based on baseline data on cognition, atrophy, amyloid-status, and tau-status into Probable- and Possible-LATE, co-occurring LATE and AD (LATE-AD), and AD (without LATE). Next, we compared these groups on demographics, clinical features, cognition, and atrophy. RESULTS: < 0.01). DISCUSSION: Using an operationalization of clinical criteria for LATE, 8.2% of participants with MCI or dementia from our tertiary memory clinic were classified as Possible-LATE, Probable-LATE, or LATE-AD. Probable-LATE was characterized by a milder disease course than AD, whereas LATE-AD was characterized by a more aggressive disease course. This underscores the value of the proposed clinical criteria in identifying individuals with suspected LATE, who have distinct clinical trajectories from AD. Our findings, therefore, support the use of these criteria to improve diagnostic and prognostic accuracy in the memory clinic.

NeurologyVol. 106(9)
Netherlands Institute for Neuroscience (NL), Harvard University (US), Lund University (SE), Gordon Center for Medical Imaging (US), Amsterdam Neuroscience (NL), Instituto de Neurología Cognitiva (AR), Alzheimer Nederland (NL), Public Health Service of Amsterdam (NL), National Hospital for Neurology and Neurosurgery (GB), The Memory Clinic (US), University College London (GB), Vrije Universiteit Amsterdam (NL)
Quality Education
Openalex Percentile: Top 1%
Traumatic Brain Injury Research
20.01
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