Integrated mapping of human meniscus and cartilage eQTLs reveals shared and distinct osteoarthritis genetic drivers
. Exploratory analysis suggested candidate compounds to reverse pathogenic gene expression. Our findings underscore the meniscus as a distinct genetic driver, molecularly reinforcing OA as an entire joint organ failure.
Authors
- Yuki Naito (ORCID: https://orcid.org/0000-0002-1182-6786)
- Mahoko Takahashi Ueda (ORCID: https://orcid.org/0000-0002-3960-0922)
- Hiroshi Asahara (ORCID: https://orcid.org/0000-0002-5215-8745)
- Tomoki Chiba (ORCID: https://orcid.org/0000-0001-5472-9030)
- Takahide Matsushima (ORCID: https://orcid.org/0000-0002-7110-2261)
- Ryo Nakamichi (ORCID: https://orcid.org/0000-0002-0145-2135)
- Yuta Fujii (ORCID: https://orcid.org/0000-0002-6304-7020)
- Yuta Kochi
- Yutaro Uchida
- Martin Lotz
- Merissa Olmer
- Kenji Takahashi
- Hannah Swahn
Institutions
- Scripps Research Institute (US)
- Kyoto Prefectural University of Medicine (JP)
- Tokyo Metropolitan Institute of Medical Science (JP)
- Institute for Biomedicine (IT)
Publication Details
- Journal
- medRxiv
- Published
- 2026-04-16
- DOI
- https://doi.org/10.64898/2026.04.12.26350702
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00