Spathulenol, a Sesquiterpene from <i>Guarea macrophylla</i> , Displays Potent and Selective <i>Anthelmintic</i> Activity against <i>Angiostrongylus cantonensis</i>
at concentrations up to 1000 μM. Taken together, these findings identify spathulenol as a selective hit compound emerging from phenotypic screening, representing a promising scaffold for early-stage anthelmintic drug discovery.
Authors
- Marina M. Gonçalves (ORCID: https://orcid.org/0000-0003-0962-7224)
- João Henrique G. Lago (ORCID: https://orcid.org/0000-0002-1193-8374)
- Josué de Moraes (ORCID: https://orcid.org/0000-0003-1766-7031)
- Lucas Fukui-Silva (ORCID: https://orcid.org/0009-0006-8829-7604)
- Camila S. Amorim
- Roberto Baptista P. de Almeida
- Juliana M. Santos (ORCID: https://orcid.org/0009-0009-0495-3611)
- Igor S. Alborghetti
- João Pedro V. Moriconi
Institutions
- Drugs for Neglected Diseases Initiative (CH)
- Institute of Botany (AZ)
- Guarulhos University (BR)
- Institute of Botany (AM)
- Universidade Federal do ABC (BR)
Publication Details
- Journal
- ACS Omega
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1021/acsomega.6c01587
- Primary Topic
- Mollusks and Parasites Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico