Repeated mutation of a GT92 glycosyltransferase gene confers antiviral resistance in two <i>Caenorhabditis</i> species
orthologs, which repeatedly lead to viral resistance yet remain at low frequency. These repeated events provide a case of transient ecological adaptation to a pathogen through recurrent mutation of the same gene in two species. The low population frequencies of the resistant alleles point to a changing eco-evolutionary context that prevents their spread in populations, resulting in high allelic heterogeneity.
Authors
- Aurélien Richaud
- Eillen Tecle (ORCID: https://orcid.org/0000-0003-4253-1128)
- Cigdem Alkan (ORCID: https://orcid.org/0000-0002-1302-9270)
- Gaotian Zhang (ORCID: https://orcid.org/0000-0001-6468-1341)
- Daria Martynow (ORCID: https://orcid.org/0000-0003-1085-1063)
- Nanako Takeda
- Tony Bélicard (ORCID: https://orcid.org/0000-0002-3756-4729)
- Marie‐Anne Félix
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Medical College of Wisconsin (US)
- Institut de Biologie de l'École Normale Supérieure (FR)
- The University of Texas Medical Branch at Galveston (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-16
- DOI
- https://doi.org/10.64898/2026.04.14.718442
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00