Cancer-associated adipocyte promote progression and immunosuppression in triple-negative breast cancer
T cell infiltration. In conclusion, this study demonstrates that CAA promotes TNBC progression by activating epithelial-mesenchymal transition (EMT) and the PI3K/AKT pathway, as well as remodeling an immunosuppressive microenvironment, providing experimental insight into tumor-adipocyte interactions and identifying potential therapeutic targets.
Authors
- Shan Liu (ORCID: https://orcid.org/0000-0001-9932-0175)
- Xiaofeng Mu (ORCID: https://orcid.org/0000-0003-0780-0812)
- Shenjie Zhong
- Gang Chen
- Xichao Zhang
- Wen Chen
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- National Rehabilitation Center (KR)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-04-16
- DOI
- https://doi.org/10.3389/fonc.2026.1797152
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00