Clinical application of ozone hydrotherapy combined with scalp complex acid treatment for moderate to severe scalp seborrheic dermatitis

Introduction: This study evaluates the effectiveness of combining ozone hydrotherapy with scalp complex acid in treating scalp seborrheic dermatitis (SSD). Methods: A total of 96 patients with moderate to severe SSD were randomly assigned to either the Control group (treated with scalp complex acid) or the Observation group (treated with a combination of ozone hydrotherapy and scalp complex acid). The treatment period lasted 4 weeks. SSD severity was evaluated using a 16-point composite score that assessed erythema, scaling, and pruritus. Total skin damage score was rated on a 4-point scale. Scalp sebum levels were measured using a Sebumeter SM 810, and serum levels of IL-1β and TNF-α were quantified using enzyme-linked immunosorbent assay. Results: < 0.001). Discussion: The combination of ozone hydrotherapy and scalp complex acid showed enhanced therapeutic benefits for SSD, leading to improved clinical outcomes and a reduction in systemic inflammation.

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Publication Details

Journal
Frontiers in Medicine
Published
2026-04-16
DOI
https://doi.org/10.3389/fmed.2026.1791653
Primary Topic
Medical and Biological Ozone Research
Type
article
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0.00
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article

Clinical application of ozone hydrotherapy combined with scalp complex acid treatment for moderate to severe scalp seborrheic dermatitis

Sui Liu, Jun Chen, Qianqian Xu, Yiying Ma et al.
Frontiers in Medicine
Medical and Biological Ozone Research
article

Clinical application of ozone hydrotherapy combined with scalp complex acid treatment for moderate to severe scalp seborrheic dermatitis

Sui Liu, Jun Chen, Qianqian Xu, Yiying Ma, Xiaoxia Shi, Fangling Wang
article en

Abstract

Introduction: This study evaluates the effectiveness of combining ozone hydrotherapy with scalp complex acid in treating scalp seborrheic dermatitis (SSD). Methods: A total of 96 patients with moderate to severe SSD were randomly assigned to either the Control group (treated with scalp complex acid) or the Observation group (treated with a combination of ozone hydrotherapy and scalp complex acid). The treatment period lasted 4 weeks. SSD severity was evaluated using a 16-point composite score that assessed erythema, scaling, and pruritus. Total skin damage score was rated on a 4-point scale. Scalp sebum levels were measured using a Sebumeter SM 810, and serum levels of IL-1β and TNF-α were quantified using enzyme-linked immunosorbent assay. Results: < 0.001). Discussion: The combination of ozone hydrotherapy and scalp complex acid showed enhanced therapeutic benefits for SSD, leading to improved clinical outcomes and a reduction in systemic inflammation.

Frontiers in MedicineVol. 13
Suizhou Central Hospital (CN)
Openalex Percentile: Top 22%
Medical and Biological Ozone Research
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