Catalyst-Free Photoinduced Deaminative Functionalization of Amino Acids and Glutarimide Precursors
, which are displaced by the introduction of an exogenous nucleophile. Overall, this transformation introduces an umpolung approach to heteroarylation by converting primary amines into electrophilic coupling partners. When employing glutamate and glutamine derivatives, this strategy can enable efficient late-stage introduction of glutarimides.
Authors
- Julia R. Dorsheimer (ORCID: https://orcid.org/0000-0002-0675-5928)
- Candice L. Joe (ORCID: https://orcid.org/0000-0002-7167-2416)
- Trevor C. Sherwood (ORCID: https://orcid.org/0000-0003-3070-6373)
- Tyler G. Chong
- Tomislav Rovis (ORCID: https://orcid.org/0000-0001-6287-8669)
- Eric R. Welin (ORCID: https://orcid.org/0000-0002-1760-4121)
- Zixi Zhu
Institutions
- Bristol-Myers Squibb (Germany) (DE)
- Bristol-Myers Squibb (United States) (US)
- Université Bourgogne Franche-Comté (FR)
- Columbia University (US)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1021/jacs.6c04839
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bristol-Myers Squibb
- NIH Office of the Director
- National Institute of General Medical Sciences