Using X-ray Crystallography and 1, <i>n</i> -ADEQUATE NMR to Revise the Structures of Highly Substituted Aromatic Natural Products: The Absolute Configuration of Formicamycin Congeners
-ADEQUATE experiments for regiochemical determination in polysubstituted aromatic molecules. Moreover, our investigations uncovered a potential deracemization step during biosynthesis of the formicamycin framework.
Authors
- Joseph A. Wright (ORCID: https://orcid.org/0000-0001-9603-1001)
- Barrie Wilkinson (ORCID: https://orcid.org/0000-0001-7646-7174)
- Julia E. A. Mundy (ORCID: https://orcid.org/0009-0006-6232-7254)
- Sergey A. Nepogodiev (ORCID: https://orcid.org/0000-0001-9796-4612)
- David M. Lawson (ORCID: https://orcid.org/0000-0002-7637-4303)
- Sandra Eltschkner (ORCID: https://orcid.org/0000-0002-9854-0800)
- David L. Hughes (ORCID: https://orcid.org/0000-0003-0621-204X)
- Corinne Arnold (ORCID: https://orcid.org/0000-0001-5140-103X)
- Matthew I. Hutchings (ORCID: https://orcid.org/0000-0001-6628-5940)
- Rebecca Devine (ORCID: https://orcid.org/0000-0003-0008-2184)
- Edward S. Hems
Institutions
- John Innes Centre (GB)
- University of East Anglia (GB)
- Norwich Research Park (GB)
- Center for Interdisciplinary Studies of Molecular Interactions (DK)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1021/acs.jnatprod.6c00145
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Diamond Light Source
- Biotechnology and Biological Sciences Research Council