Stem cell control in the lung by an autocrine injury-activated Igf complex
deletion initiated continuous stem cell division. Thus, beyond their classical hormonal roles in physiology, growth, and aging, Igf proteins operate locally and rapidly with Igfbp and Rb to control injury-induced stem cell proliferation and tumor initiation.
Authors
- Mark A. Krasnow (ORCID: https://orcid.org/0000-0002-1976-5471)
- Maya E. Kumar (ORCID: https://orcid.org/0000-0001-6754-5660)
- Makenna M. Morck (ORCID: https://orcid.org/0000-0001-7561-892X)
- Yue Zhang (ORCID: https://orcid.org/0000-0002-2955-7780)
- Youcef Ouadah
Institutions
- Howard Hughes Medical Institute (US)
- Stanford University (US)
Publication Details
- Journal
- Science
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1126/science.adt1310
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Howard Hughes Medical Institute
- National Institutes of Health