Angiopoietin-2 and Growth Differentiation Factor-15 as Predictors of Device-Detected Atrial Fibrillation Burden
: In continuously monitored pacemaker patients, ANGPT2 and GDF-15 emerged as key biomarkers associated with AF disease severity. ANGPT2 was strongly linked to both progression to persistent AF and high AF burden, whereas GDF-15 consistently predicted higher AF burden and also contributed to risk of progression. These findings highlight endothelial and inflammatory pathways as potential markers of atrial disease progression.
Authors
- Wolfgang Dichtl (ORCID: https://orcid.org/0000-0002-0421-2110)
- Axel Bauer (ORCID: https://orcid.org/0000-0001-9201-8555)
- Peter Willeit (ORCID: https://orcid.org/0000-0002-1866-7159)
- Philipp Spitaler (ORCID: https://orcid.org/0000-0002-5908-2923)
- Valentin Bilgeri (ORCID: https://orcid.org/0009-0006-4889-2177)
- Patrick Rockenschaub (ORCID: https://orcid.org/0000-0002-6499-7933)
- Moritz Messner (ORCID: https://orcid.org/0000-0003-3250-4353)
- Fabian Barbieri (ORCID: https://orcid.org/0000-0003-4456-1822)
- Agnė Adukauskaitė
- Bernhard Pfeifer (ORCID: https://orcid.org/0000-0003-1507-1015)
- Markus Stühlinger (ORCID: https://orcid.org/0000-0003-1324-0815)
- Gudrun Feuchtner (ORCID: https://orcid.org/0000-0001-6755-4399)
- Theresa Dolejsi (ORCID: https://orcid.org/0000-0002-1356-2171)
- Pietro G. Lacaita (ORCID: https://orcid.org/0009-0008-4049-4494)
- Jasmina Gavranovic-Novakovic
- Marc Michael Zaruba
Institutions
- Innsbruck Medical University (AT)
- Universität Innsbruck (AT)
- University of Cambridge (GB)
- Humboldt-Universität zu Berlin (DE)
- Deutsches Herzzentrum der Charité (DE)
- UMIT - Private Universität für Gesundheitswissenschaften, Medizinische Informatik und Technik (AT)
- Tirol Kliniken (AT)
- Helmholtz-Zentrum Hereon (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Biomedicines
- Published
- 2026-04-16
- DOI
- https://doi.org/10.3390/biomedicines14040902
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- MicroPort