Fenofibrate Mitigates Acute Lung Injury in a Rat Model of Feces-Induced Peritonitis
< 0.01). Fenofibrate attenuates sepsis-induced acute lung injury by reducing inflammation and oxidative stress while preserving HSP-70 and Nrf2-mediated cytoprotective pathways. These findings are clinically relevant to general surgery, as septic lung injury commonly arises from colon-origin abdominal sepsis, including colonic perforation and anastomotic leakage.
Authors
- Oytun Erbaş (ORCID: https://orcid.org/0000-0001-5427-8428)
- Mehmet Fatih DAŞIRAN
- Ahmet Akbaş (ORCID: https://orcid.org/0000-0002-6333-4919)
- Yiğit Uyanıkgil (ORCID: https://orcid.org/0000-0002-4016-0522)
- Bakiye Akbaş (ORCID: https://orcid.org/0000-0003-2480-1374)
- Hatice Aygün (ORCID: https://orcid.org/0000-0002-4272-0562)
- Gülçin Ercan (ORCID: https://orcid.org/0000-0001-8420-9298)
- Hassen Daghmoura
- Ahmet Serdaroglu (ORCID: https://orcid.org/0000-0001-6893-2419)
Institutions
- Karadeniz Technical University (TR)
- Tokat Gaziosmanpaşa Üniversitesi (TR)
- Bezmiâlem Vakıf Üniversitesi (TR)
- Ege University (TR)
- Biruni University (TR)
- Fatih Sultan Mehmet Eğitim Ve Araştırma Hastanesi (TR)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2026-04-16
- DOI
- https://doi.org/10.3390/ijms27083556
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00