Patterns of Mouse Allergen–Specific <scp>IgE</scp> and <scp>IgG4</scp> in Contemporary Animal Research Environments
Summary Mouse‐sensitised laboratory workers without asthma symptoms have higher mouse‐specific IgG4 than those with symptoms. Mouse‐specific IgG4 in workers' serum is associated with inhibiting IgE‐allergen complex binding to B cells.
Authors
- J Feary
- Susie J. Schofield (ORCID: https://orcid.org/0000-0002-3135-9783)
- Mohamed H. Shamji (ORCID: https://orcid.org/0000-0003-3425-3463)
- Jennifer Canizales
- Paul Cullinan (ORCID: https://orcid.org/0000-0002-9314-6468)
- M. C. Jones
Institutions
- London Health Sciences Centre (CA)
- NIHR Imperial Biomedical Research Centre (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Clinical & Experimental Allergy
- Published
- 2026-04-16
- DOI
- https://doi.org/10.1111/cea.70307
- Primary Topic
- Occupational exposure and asthma
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- Colt Foundation