γ-Butyrolactone-induced coelimycin synthesis inhibits AtrA-dependent actinorhodin overproduction in <i>Streptomyces coelicolor</i> A3(2)
A3(2). We show that even the products of BGCs can have a regulatory function. The richness of potentially competing biosynthetic pathways may hinder high-yield biosynthesis of the desired product under fermentation conditions. Our results show the importance of designing host organisms with lowered background regulation by γ-butyrolactones for the desired biosynthetic pathway activation.
Authors
- Krzysztof Pawlik (ORCID: https://orcid.org/0000-0002-5881-9292)
- Jarosław Ciekot (ORCID: https://orcid.org/0000-0001-6883-2338)
- Michał Tracz (ORCID: https://orcid.org/0000-0001-7510-5024)
- Bartosz Bednarz (ORCID: https://orcid.org/0000-0003-3983-5868)
- Magdalena Kotowska (ORCID: https://orcid.org/0000-0002-5000-454X)
- Mateusz Wenecki (ORCID: https://orcid.org/0000-0002-3770-0102)
- Marta Derkacz (ORCID: https://orcid.org/0000-0001-7295-9833)
- Adrianna Jastrzemska
- Lizaveta Karpovich
Institutions
- University of Wrocław (PL)
- Ludwik Hirszfeld Institute of Immunology and Experimental Therapy (PL)
Publication Details
- Journal
- mBio
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1128/mbio.00630-26
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00