Subcutaneous Adipose Tissue Accumulation is Associated With an Improved Prognosis in Patients With Hepatocellular Carcinoma
AIM: This study investigated the effects of the subcutaneous adipose tissue index (SATI) and visceral adipose tissue index (VATI) on the overall survival (OS) of patients with hepatocellular carcinoma (HCC). METHODS: This study included 587 patients with HCC. The Cox proportional hazards model was used to identify independent prognostic factors. The optimal SATI cutoff value that yielded the most significant differences in OS was determined using the maximally selected statistics. Survival was estimated using the Kaplan-Meier method, and differences between survival curves were evaluated using the log-rank test. RESULTS: , or hyperlipidemia. CONCLUSIONS: In the absence of findings indicative of ectopic lipid accumulation, SAT accumulation is associated with an improved prognosis in patients with HCC.
Authors
- Kenji Imai (ORCID: https://orcid.org/0000-0001-5965-746X)
- Shinji Unome (ORCID: https://orcid.org/0000-0001-6185-4796)
- Atsushi Suetsugu
- Masashi Aiba
- Takao Miwa (ORCID: https://orcid.org/0000-0002-6373-260X)
- Hiroyasu Sakai (ORCID: https://orcid.org/0000-0002-2767-9063)
- Yohei Shirakami (ORCID: https://orcid.org/0000-0002-2471-090X)
- Mikita Oi
- Koji Takai
- Masahito Shimizu (ORCID: https://orcid.org/0000-0002-1151-2058)
Institutions
- Gifu University (JP)
Publication Details
- Journal
- Hepatology Research
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1111/hepr.70187
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development