PIKfyve mediates the maturation of mycobacteria-containing vesicles
-containing vesicle trafficking towards degradative lysosomes. We found that in the infected macrophages, PIKfyve facilitates autophagy pathway activation and (auto)phagosome maturation, and protects against cell death, thus boosting the host immune response against mycobacterial infection. This study links PIKfyve to the autolysosomal defense against a mycobacterial pathogen.
Authors
- Salomé Muñoz‐Sánchez (ORCID: https://orcid.org/0009-0000-2845-6841)
- Annemarie H. Meijer (ORCID: https://orcid.org/0000-0002-1325-0725)
- Michiel van der Vaart (ORCID: https://orcid.org/0000-0003-0828-7088)
Institutions
- Leiden University (NL)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-04-15
- DOI
- https://doi.org/10.3389/fcimb.2026.1792069
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Toegepaste en Technische Wetenschappen, NWO
- H2020 Marie Skłodowska-Curie Actions