Current Perspective on Orthobiology Applications for the Treatment of Intervertebral Disc Degeneration (IDD)—A Narrative Review
: MSCs and PRP represent a promising and, eventually, complementary orthobiologic therapies for IVDD. PRP is primarily effective in early degenerative stages as a biologic stimulator, whereas MSCs may provide regenerative benefits in more advanced but still viable discs. Further studies are necessary to standardize protocols and confirm long-term efficacy and safety.
Authors
- Giuseppe Toro (ORCID: https://orcid.org/0000-0002-8560-721X)
- Caterina Claudia Lepre (ORCID: https://orcid.org/0000-0002-9041-1043)
- Gabriella Toro
- Gianluca Conza (ORCID: https://orcid.org/0009-0003-7621-4013)
- Marina Russo (ORCID: https://orcid.org/0000-0003-2011-6353)
- Maria Consiglia Trotta (ORCID: https://orcid.org/0000-0001-9813-5955)
- A Itro (ORCID: https://orcid.org/0000-0002-0226-7521)
- Gabriele Martin
- Alfonso Nocera (ORCID: https://orcid.org/0009-0001-9971-0808)
- Chiara Mastronardi
Institutions
- University of Campania "Luigi Vanvitelli" (IT)
- Ospedale San Paolo (IT)
Publication Details
- Journal
- Medicina
- Published
- 2026-04-15
- DOI
- https://doi.org/10.3390/medicina62040758
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00