Case Report: Integrative management of refractory fibromyalgia with pulsed electromagnetic fields and ozone therapy: a case series

Fibromyalgia is a complex, heterogeneous and often disabling syndrome that seriously affects the quality of life of patients. It is characterized by chronic widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive impairment. Its pathophysiology remains poorly understood, and conventional treatments often offer limited efficacy while carrying significant side effects, highlighting the urgent need for alternative therapeutics strategies. We report a retrospective case series evaluating a novel protocol that combines low frequency Pulsed Electromagnetic Field (PEMF) therapy, medical ozone insufflation, and targeted nutritional supplementation in three patients with refractory fibromyalgia who had previously shown inadequate response to conventional treatments. Following the intervention, patients experienced substantial pain relief and significant improvement in quality of life, which were sustained at the 30-day follow-up assessment. These findings suggest that the combination of PEMF and ozone therapy may induce durable physiological benefits, presenting a promising complementary strategy for managing refractory fibromyalgia.