Radiation Shielding, Therapeutic and Dosimetric Properties of Newly Designed 7-Dimethylaminocoumarin-Chalcone (DACC) Derivatives: A Study on Gamma Radiation Interaction Parameters

Abstract Objective: To investigate the gamma-radiation interaction parameters of newly designed 7-dimethylaminocoumarin-chalcone (DACC) derivatives and to assess the influence of structural modifications on their shielding and dosimetric properties. Methods: A set of 33 DACC derivatives was studied using computational approaches. Key gamma interaction parameters mass and linear attenuation coefficients, mean free path, half- and tenth-value layers, effective atomic and electron numbers, equivalent atomic number, buildup factors, radiation absorption dose, and dose rate were evaluated across a wide photon energy range. Results: The findings demonstrate that substituent groups significantly affect radiation interaction characteristics. Halogenated derivatives, particularly those containing bromo, chloro, and fluoro groups, exhibited superior attenuation with higher effective atomic numbers, reduced mean free paths, and lower buildup factors compared to unsubstituted compounds. Dose and dose rate analyses confirmed their enhanced ability to absorb gamma radiation, especially in low-energy regions where the photoelectric effect dominates. Conclusion: Structural modifications in DACC derivatives play a critical role in improving their gamma-radiation shielding competence. Halogen-substituted derivatives show strong potential for medical radiation shielding, dosimetry, and therapeutic applications. These results establish a framework for developing novel organic-based radiation-protective materials derived from coumarin-chalcone chemistry.