The efficacy of manganese sulfate as a negative contrast agent for magnetic resonance cholangiopancreatography

The current study aims to find an alternate oral contrast media for use in magnetic resonance cholangiopancreatography (MRCP) that satisfies the following criteria, the greatest imaging quality safety, no or few side effects, and low cost. The present study created an oral contrast agent sample (solution) by dissolving a one tablet of manganese sulfate supplement (taken daily dose) in 200 ml of distilled water. Thirty-three volunteers assessed the sample using MRCP examine pre and post contrast. By evaluating the signal intensity to compute contrast (C), signal to noise ratios (SNR), and contrast to noise ratio (CNR), the resulting MR images were quantitatively evaluated. And the radiologist examined the MRCP questionnaire, which was used for the qualitative evaluation. The results indicated substantial differences before and after manganese sulfate supplement consumption, as well as enhanced quality of images following manganese sulfate consumption of the biliary systems.