Early Adverse Experiences and the Likelihood of Substance Use Disorders and Non-Fatal Overdose in Clinical and Community Settings: A Systematic Review and Meta-Analysis
= 28.4%). A Hartung-Knapp sensitivity analysis yielded OR 1.16 (0.95-1.41). Risk of bias was mostly moderate, commonly driven by self-reported outcomes and residual confounding. Early adverse experiences were associated with higher odds of SUD and non-fatal overdose across settings. Limitations include observational designs, variable measurement, and sparse poolable overdose evidence; future studies should distinguish fatal from non-fatal overdose and improve outcome harmonisation.
Authors
- Omar Rozo-Pérez
- Olga Mariela Mogollón Canal (ORCID: https://orcid.org/0000-0001-9546-3435)
- Javier Fernández‐Montalvo (ORCID: https://orcid.org/0000-0001-5946-1934)
- Diego Rivera-Porras (ORCID: https://orcid.org/0000-0003-2169-3208)
- Daniel Cepeda-Pineda (ORCID: https://orcid.org/0009-0006-8677-2731)
- Sandra Licette Padilla-Sarmiento
- Diana Janeth Villamizar-Carrillo
- Anyela Patricia Villamizar-Carrillo
- Sandra-Milena Carrillo-Sierra
Institutions
- Universidad de La Sabana (CO)
- Universidad Pública de Navarra (UPNA) (ES)
- University of the Coast (CO)
- Universidad Simón Bolívar (CO)
- University of Pamplona (CO)
Publication Details
- Journal
- Behavioral Sciences
- Published
- 2026-04-15
- DOI
- https://doi.org/10.3390/bs16040589
- Primary Topic
- Opioid Use Disorder Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad Simón Bolívar