Reaction hijacking of enzymes to generate potent therapeutic modulators in situ
-metabolising enzymes, and a range of cofactor-dependent enzymes. Hijacking compounds are usually unreactive until activated by the target enzyme, affording good selectivity and potency, as well as favourable physiochemical properties and synthetic tractability.
Authors
- Leann Tilley (ORCID: https://orcid.org/0000-0001-9910-0199)
- Craig J. Morton (ORCID: https://orcid.org/0000-0001-5452-5193)
- Boštjan Kobe (ORCID: https://orcid.org/0000-0001-9413-9166)
- Stanley C. Xie (ORCID: https://orcid.org/0000-0001-7003-4677)
- Yun Shi
Institutions
- The University of Queensland (AU)
- The University of Melbourne (AU)
- CSIRO Manufacturing (AU)
- Monash University (AU)
Publication Details
- Journal
- Trends in Biochemical Sciences
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1016/j.tibs.2026.03.003
- Primary Topic
- Enzyme Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Australian Research Council
- National Health and Medical Research Council
- National Center for Medical Rehabilitation Research