Sequence-Dependent Analgesic Efficacy of Ketamine and Magnesium Sulfate After Radical Nephrectomy
(K → Mg) provides clinically meaningful postoperative analgesia after open radical nephrectomy; the reversed sequence (Mg → K) offers no benefit over placebo. These findings provide the first clinical confirmation of sequence-dependent NMDA receptor antagonism and support the K → Mg protocol as a safe, simple addition to multimodal perioperative analgesia. Trial registration: ISRCTN registry, ISRCTN83633282.
Authors
- Miloš Lazić (ORCID: https://orcid.org/0009-0009-2678-7597)
- Nebojša Ladjević (ORCID: https://orcid.org/0000-0001-9569-4954)
- Zoran Džamić (ORCID: https://orcid.org/0009-0001-8953-2294)
- Nataša Petrović (ORCID: https://orcid.org/0009-0003-3548-8659)
- Branka Terzić
- Svetlana Srećković (ORCID: https://orcid.org/0000-0002-7225-4961)
- Nikola N. Ladjevic (ORCID: https://orcid.org/0000-0003-1243-2639)
- Ivana Likic Ladjevic (ORCID: https://orcid.org/0000-0001-9743-2528)
Institutions
- University of Belgrade (RS)
- Center for Health, Exercise and Sport Sciences (RS)
- Centar za Promociju Nauke (RS)
- University Clinical Centre (PL)
Publication Details
- Journal
- Medicina
- Published
- 2026-04-15
- DOI
- https://doi.org/10.3390/medicina62040754
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00