A T-Cell Epitope Tandem Peptide Designed from Two Major Allergens of <i>Crassostrea angulata</i> Shows Potential for Inducing Dual Immune Tolerance
T cells, promote Treg cell differentiation, and upregulate the secretion of interleukin-10. Moreover, serological assays confirmed that Cra a T exhibited markedly reduced immunobinding activity against both Cra a 1 and Cra a 2. Overall, hypoallergenic Cra a T has the potential to induce dual immune tolerance and is a candidate for oyster oral desensitization preparations.
Authors
- Lingna Ni
- Fei Huan
- Mingxuan Wu (ORCID: https://orcid.org/0000-0003-4721-0825)
- Guang‐Ming Liu (ORCID: https://orcid.org/0000-0002-8689-0504)
- Xin-Yi Huang
- Yi Gu
- Dong Lai
- Yang Yang
- Meng Liu
- Shuai Gao
Institutions
- Jimei University (CN)
- Tianma Microelectronics (China) (CN)
- Intelligent Health (United Kingdom) (GB)
- The Second Affiliated Hospital of Xiamen Medical College
- College of Marin (US)
Publication Details
- Journal
- Journal of Agricultural and Food Chemistry
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1021/acs.jafc.6c02233
- Primary Topic
- Allergic Rhinitis and Sensitization
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Xiamen City
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province