Single-cell transcriptomics reveals pediatric immune responses to COVID-19 vaccination
signaling to restrain excessive cytotoxicity and orchestrate helper T cell differentiation. Together, our atlas demonstrates that pediatric immunity to inactivated vaccines is tightly orchestrated, balancing antiviral programs with regulatory mechanisms to ensure safe protection.
Authors
- Xiaolan Huang (ORCID: https://orcid.org/0000-0002-7865-0009)
- Li Wan (ORCID: https://orcid.org/0000-0002-0531-4573)
- Zhaomin Feng (ORCID: https://orcid.org/0000-0002-2559-7662)
- 贾楠
- Xiong Zhu (ORCID: https://orcid.org/0000-0002-2594-875X)
- 付锦
- Juan Zhou
- Fei Xiao
- Yi Wang
- Jie Wang (ORCID: https://orcid.org/0000-0003-3366-2783)
- Quanyi Wang
- Xiaoxia Wang
- Min Chen
- Lin Sun
Institutions
- Capital Medical University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Capital Institute of Pediatrics (CN)
- Sanya Central Hospital (CN)
- Beijing Center for Disease Prevention and Control (CN)
Publication Details
- Journal
- iScience
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1016/j.isci.2026.115769
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 0.00