Optimization, characterization, and protective potentials of Periploca angustifolia extract against cadmium toxicity using response surface methodology as an optimizing tool

Introduction: Phenolic compounds isolated from medicinal plants are used against several physiological disorders. Methods: extract (PAPE). The phenolic extract was characterized by nuclear magnetic resonance (NMR) spectroscopy. The antioxidant activity of the extract was evaluated using standard antioxidant assays. In addition, the protective effect of the phenolic extract was evaluated against cadmium toxicity. Results and discussion: < 0.01) protective effect against oxidative damage induced by cadmium exposure in rat testicles. In conclusion, PAPE demonstrated strong antioxidant potential that is likely attributable to the active compounds present in the extract.