Direct Synthesis of γ-Keto Sulfones via Bronsted Acid-Promoted Tandem Sulfonylation of Propargylic Esters with RSO <sub>2</sub> H
H under metal-free and oxidant-free conditions. The novel transformation proceeds through α,β-unsaturated ketone intermediates as the key intermediate, which then undergoes thia-Michael addition with sulfinic acids to afford the target γ-keto sulfones in moderate to excellent yields. The key merits of this approach include operational simplicity, the avoidance of metals and oxidants, and good functional group tolerance.
Authors
- Qiang Xiao (ORCID: https://orcid.org/0000-0003-2812-7778)
- Yaping Han (ORCID: https://orcid.org/0000-0002-5839-225X)
- Mu‐Jia Luo (ORCID: https://orcid.org/0000-0001-5827-749X)
- X H Chen
- 潘求全
- Xian‐Rong Song (ORCID: https://orcid.org/0000-0002-8547-7881)
- Zixin Zhang
- Fengyan Jin
- Xingyue Wang
Institutions
- Hebei University of Technology (CN)
- Jiangxi Science and Technology Normal University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1021/acs.joc.6c00509
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province
- Education Department of Jiangxi Province
- Jiangxi Science and Technology Normal University