Methyl maleopimarate <i>N</i> -Hydroxy-imide as an acid isostere in the Ugi reaction for one-pot synthesis of α-hydrazino-amides

An efficient one-pot method for the synthesis of diterpene α-hydrazino-amides with high yields has been developed using N-hydroxyimide methyl maleopimarate as a novel carboxylic acid isostere in the conditions of the four-component Ugi reaction.

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Publication Details

Journal
Natural Product Research
Published
2026-04-15
DOI
https://doi.org/10.1080/14786419.2026.2657033
Primary Topic
Multicomponent Synthesis of Heterocycles
Type
article
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article

Methyl maleopimarate N -Hydroxy-imide as an acid isostere in the Ugi reaction for one-pot synthesis of α-hydrazino-amides

Anna Smirnova, E. V. Tret’yakova
Natural Product Research
Multicomponent Synthesis of Heterocycles
article

Methyl maleopimarate N -Hydroxy-imide as an acid isostere in the Ugi reaction for one-pot synthesis of α-hydrazino-amides

Anna Smirnova, E. V. Tret’yakova
article en

Abstract

An efficient one-pot method for the synthesis of diterpene α-hydrazino-amides with high yields has been developed using N-hydroxyimide methyl maleopimarate as a novel carboxylic acid isostere in the conditions of the four-component Ugi reaction.

Natural Product Research
Ufa Institute of Chemistry (RU)
Openalex Percentile: Top 15%
Multicomponent Synthesis of Heterocycles
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Methyl maleopimarate <i>N</i> -Hydroxy-imide as an acid isostere in the Ugi reaction for one-pot synthesis of α-hydrazino-amides — Anna Smirnova, E. V. Tret’yakova · Natural Product Research (2026) | TGRS Research Map | TGRS