MT1-MMP-Targeted Photoimmunotherapy via an IR700-Conjugated Bicyclic Peptide
significantly inhibited tumor growth relative to light-only and drug-only controls. These findings demonstrate that MT1-MMP-targeted bicyclic peptide-mediated PIT constitutes a viable nonantibody alternative, justifying further optimization of dosing, illumination parameters, and immunocompetent models to fully define its therapeutic potential.
Authors
- Ayaka Kanai
- Hirofumi Hanaoka (ORCID: https://orcid.org/0000-0003-2421-7397)
- Naoya Kondo
- Takuya Otani
Institutions
- Kansai Medical University (JP)
Publication Details
- Journal
- Bioconjugate Chemistry
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1021/acs.bioconjchem.5c00593
- Primary Topic
- Photodynamic Therapy Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Science and Technology Corporation
- Japan Society for the Promotion of Science