Toll of Chronic Metabolic Acidosis at Molecular, Cellular, and Systemic Levels: A Conceptual Framework to Revisit Type 2 Diabetes (T2D) Pathophysiology
: The alignment between the effects of CMA and the clinical features of T2D suggests that T2D pathophysiology is worth revisiting through the lens of CMAD. This perspective is further supported by therapeutic interventions showing preliminary efficacy signals in limited studies of acid-neutralization in managing T2D symptoms and progression.
Authors
- Hayder A. Giha (ORCID: https://orcid.org/0000-0001-6343-1949)
- Mai S. Sater (ORCID: https://orcid.org/0000-0003-3571-8648)
Institutions
- The Queen's Medical Research Institute (GB)
- Arabian Gulf University (BH)
Publication Details
- Journal
- Biomedicines
- Published
- 2026-04-15
- DOI
- https://doi.org/10.3390/biomedicines14040901
- Primary Topic
- Renal function and acid-base balance
- Type
- article
- Field-Weighted Citation Impact
- 0.00