Synergistic action of JNK activation and BChE inhibition: a novel anti- glioblastoma compound with neuroprotective profile
OBJECTIVE: can be used to treat glioblastoma (GBM) and exert a neuroprotective profile. METHODS: in normal mice, its anti-tumor effects in GBM mice, and its effects on cognition protective function were examined. RESULTS: upregulated c-jun N-terminal kinase (JNK) levels to exert an inhibitory effect on glioma. CONCLUSION: is a highly promising drug for the treatment of glioblastoma with neuroprotective profile.
Authors
- Siyu He
- Weiping Lyu
- Qi Li (ORCID: https://orcid.org/0000-0001-9660-7875)
- Ziyao Lu
- Y. B. Duan (ORCID: https://orcid.org/0009-0001-2142-553X)
- Kaixuan Wang
- Xuehong Chen
- Qinghong Liao
Institutions
- Qingdao University (CN)
- Guiyang Medical University (CN)
- Peking University (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1080/17568919.2026.2658833
- Primary Topic
- Melanoma and MAPK Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Qingdao Postdoctoral Science Foundation
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Shandong Province