A CRISPR-Based Mutagenesis Strategy for Examining CLAG3 Helix 44 Contribution to Malaria Parasite Nutrient Uptake Channels
These studies support a α-H44 role in channel permeation and block by a strain-specific inhibitor. Our strategy will enable saturation mutagenesis to determine how PSAC achieves its unique ion and nutrient selectivity and should help guide drug discovery against this antimalarial target.
Authors
- Sanjay A. Desai (ORCID: https://orcid.org/0000-0003-2150-2483)
- Sundar Ganesan (ORCID: https://orcid.org/0000-0003-1132-2016)
- Zabdi González‐Chávez
- Mansoor A. Siddiqui
Institutions
- National Institutes of Health (US)
- National Institute of Allergy and Infectious Diseases (US)
Publication Details
- Journal
- Genes
- Published
- 2026-04-15
- DOI
- https://doi.org/10.3390/genes17040462
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00