Mechanistic insights into how cichoriin inhibits P2Y14R to suppress MSU-induced gouty inflammation

BACKGROUND: Gout is a prevalent, chronic inflammatory joint diseases, and its global prevalence and incidence are continue to rise. Currently, the adverse side effects of anti-gout drugs underscore the urgent need for safer and more effective anti-gout agents. OBJECTIVE: Cichoriin is a kind of coumarin, which exhibits diversity of biological activities. The current investigation aimed to explore the mechanism of the inhibition of MSU-induced gouty inflammation by cichoriin. METHODS: R were obtained by molecular dynamics simulation. RESULTS: R by forming hydrogen bonds and hydrophobic interactions. CONCLUSIONS: This work highlighted the potential roles of cichoriin in attenuating MSU-induced gouty inflammation.