HIF-mediated regulation of glutathione-specific γ-glutamyl cyclotransferase 1 contributes to tubular cell death in renal ischemia-reperfusion injury
Here, we reported that HIF-1α upregulates glutathione-specific γ-glutamyl cyclotransferase 1 (CHAC1), a regulator of cell death and oxidative stress, in rIRI. Our results suggested that CHAC1 plays a pivotal role in regulating tubular cell death during rIRI, and the controlled tubular cell death induced by CHAC1 is essential for rIRI recovery. This proposes novel mechanisms underlying rIRI recovery.
Authors
- Panagiota Tsounapi (ORCID: https://orcid.org/0000-0002-6202-8653)
- Yoshino Fujimura
- Takujiro Homma (ORCID: https://orcid.org/0000-0003-3886-7411)
- Takehiro Yamaguchi (ORCID: https://orcid.org/0000-0002-5965-6499)
- Yoshitaka Kihira
- Shinji Matsunaga
- Shuhei Tomita
- Kunihisa Yamaguchi
- Eiji Sato
- Toshiaki Tamaki
Institutions
- Fukuyama University (JP)
- Osaka Metropolitan University (JP)
- Tottori University (JP)
- Tokushima University (JP)
Publication Details
- Journal
- American Journal of Physiology-Renal Physiology
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1152/ajprenal.00179.2025
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science