A novel photosensitizer-based photodynamic therapy reprograms the Kynurenine–AhR axis to boost antitumor immunity in breast cancer
T cells and a reduction in regulatory T cells. Notably, exogenous Kyn partially restored the Kyn-AhR axis and attenuated the immune remodeling induced by DTP-PDT. Building on these immune-activating effects, we combined DTP-PDT with PD-L1 blockade, which significantly suppressed pulmonary metastasis and enhanced central memory T-cell generation, resulting in durable systemic antitumor immunity.
Authors
- Ye Liu (ORCID: https://orcid.org/0000-0001-5827-5240)
- Ge Hong
- Hong Liu (ORCID: https://orcid.org/0009-0002-0809-9159)
- Tianjun Liu
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
Publication Details
- Journal
- Redox Biology
- Published
- 2026-04-15
- DOI
- https://doi.org/10.1016/j.redox.2026.104171
- Primary Topic
- Photodynamic Therapy Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Academy of Medical Sciences Initiative for Innovative Medicine