Fever, Rash, and Shortness of Breath in a Previously Healthy 52-Year-Old Man

A 52-year-old man had 2 days of cough, dyspnea, and fever. Physical examination showed a rash on the trunk and back with clear vesicles on an erythematous base, imaging showed pulmonary infiltrates, and results of laboratory testing were positive for varicella zoster virus DNA and negative for herpes simplex virus 1 and 2. What is the diagnosis and what would you do next?

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Publication Details

Journal
JAMA
Published
2026-04-15
DOI
https://doi.org/10.1001/jama.2026.2596
Primary Topic
Fungal Infections and Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Fever, Rash, and Shortness of Breath in a Previously Healthy 52-Year-Old Man

Paul Bellmann, Alexander Tschoner, Maximilian Lammer
JAMA
Fungal Infections and Studies
article

Fever, Rash, and Shortness of Breath in a Previously Healthy 52-Year-Old Man

Paul Bellmann, Alexander Tschoner, Maximilian Lammer
article en

Abstract

A 52-year-old man had 2 days of cough, dyspnea, and fever. Physical examination showed a rash on the trunk and back with clear vesicles on an erythematous base, imaging showed pulmonary infiltrates, and results of laboratory testing were positive for varicella zoster virus DNA and negative for herpes simplex virus 1 and 2. What is the diagnosis and what would you do next?

JAMA
Innsbruck Medical University (AT)
Good health and well-being
Openalex Percentile: Top 6%
Fungal Infections and Studies
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